Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats

Protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats

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Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction.Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties.This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress.Thirty-two male rats were used in the study.

The animals were randomly divided into 5 groups.Quercetin was dissolved DisplayPort to DVI-I in 20 mg/kg of olive oil daily for 15 days and given through oral gavage.The cecal-ligation sepsis model was applied to the group 3 and group 4.In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3).

In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group.There was a significant difference between group 3, 4, and all other groups in ALT and AST values.A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels.It was concluded that quercetin, a powerful Microphone Cable antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis.